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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110985/

QM:MM SIMULATIONS

Gamess+Tinker http://cfm.ehu.es/ricardo/master/intranet_ESCMAN/WinGAMESS/manuals/simomm.pdf (advantages: free, disadvantages: might not run well  )

Gaussian+Gromacs http://www.gromacs.org/Downloads/Installation_Instructions/compiling_QMMM (advantages: will work well, Scuzeria will likely help; disadvantages: will likely be limited to Rice U comp. resources.)

Layman news:

https://www.wired.com/2017/06/crispr-mutations/

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